Advancing Treatments for Adrenocortical Carcinoma             
ACC Research

ACC Research

The ACC Research program at TGen,  is headed by  Michael Demeure, M.D. and Kimberly Bussey, Ph.D.  The program, analyzes ACC tumors, benign adrenal tumors, and normal tissue with several genomics technologies.  TGen researchers are using the genomics data to identify mutations in the tumors.  Identifying mutations may help researchers to  design new diagnostic  tests and therapies to treat ACC.

 

                                                                                              

TGen Headquarters

TGen is  a translational research institute, where researchers are working to identify the genetic components of common and complex diseases. Translational research means that these genetic discoveries are quickly “translated” into new diagnostic tests or therapies to help patients.  These new diagnostic tests and therapies may be tailored to individual patients depending on their genetic make-up. 

 

TGen scientists work with  medical doctors and other scientists in Phoenix and around the world.  In this way, TGen researchers believe they can make a substantial contribution to the efficiency and effectiveness of the translational process.

 
 
Facts

In the past 40 years, little progress has been made toward finding an effective treatments for adrenal cancer, with only one drug calledMitotane (a derivative of DDT) being approved in the last 40 years, it is obvious that new drugs need to be tested. Adrenocortical Carcinoma affects only one or two people in a 1.7 million people and is often difficult to collect enough adrenal tumors to analyze, which is why the TGen study is so significant. With you support we can find new treatments for this devastating and rare form of adrenal cancer.



Data Sharing
Data produced from samples in this study will have all patient identifying information removed after resulting data is returned to the submitting physician (in the case of prospective submission where the patient has requested results from their tumor sample). De-identified data is published on TGen's web site, which will allow interested scientific investigators access to the data. Results of Repository studies will also be published in a timely fashion. To download the data please follow the instructions below.
To request a username and password call Dr. Bussey at 602-343-8817.


Research Techniques Used
There are a number of different kinds of research techniques that will be used to analyze samples in the ACC Repository. 
The researchers will look at the RNA, DNA and protein in the Repository samples to look for differences in the genetic make-up of people who have ACC and those who do not.  RNA, DNA and protein are found in every cell in the body.  RNA produces substances in the body (proteins) that allow your cells to function.  Genes are part of DNA.  Genes determine who you are and what you look like. 

If you are a medical professional or you would like more detailed information about the kinds of research methods that will be used to analyze the samples, click here:

TGEN RESEARCH SERVICES







Website Builder